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The maximum recommended dosage is 2 mg once weekly, and this can be considered if further control is necessary after at least 4 weeks on the 1 mg dose

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This shift in metabolic preferences has been further validated in specific cell lines, such as A549 and H1299, where SLC7A11 knockdown led to an increase in OXPHOS and a decrease in glycolysis ( in vivo , within a tumor microenvironment, where the metabolic reprogramming associated with altered SLC7A11 expression was evident (61)