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Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society , 19 (5), 426431.

10.3389/fendo.2023.1117706 31 HanY.HouY.HanQ.YuanX.ChenL

It was first identified in 1973 as an activity in human albumin that caused aged liver tissue to synthesize proteins in a more youthful pattern, and its plasma concentration is reported to decline substantially with age