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Cheroutre, H., Lambolez, F

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Bio-Rad CFX Manager 3.0 software was used for the relative quantification of mRNA expression in fold change (2 Ct ) using 18sRNA as a reference control

Upon administration to an animal or patient with a vascularized tumor, such antibodies localize to the malignant cells by virtue of the fact that vascularized tumors naturally contain necrotic tumor cells, due to the process(es) of tumor re-modeling that occur in vivo and cause at least a proportion of malignant cells to become necrotic