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Emerging evidence highlights a range of contributing factors, including reduced mechanical loading, increased bone marrow adiposity, hormonal and endocrine alterations, nutritional deficiencies, and disruptions in energy metabolism

These days' non-heart-beating donors are gaining more importance as good source of transplantable organs due to severe shortage of donor organs for clinical use

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Gastrointestinal adjustment in the first weeks mild nausea, slower digestion, occasional reflux is also widely reported and typically settles with titration

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