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Allergen immunotherapy (desensitisation) is available on the NHS for selected patients with confirmed IgE-mediated allergy who have not achieved adequate control with standard therapy, and can provide long-term relief without the need for ongoing medication

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It should be reapplied every 2-4 hours.

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A reduction in microbiome diversity has been identified (191), but it is likely that the microbiome composition will differ between ME/CFS patients as each patient has a unique infectious history (193)