In the SURMOUNT-1 trial (Jastreboff et al., NEJM 2022), adults with obesity (without diabetes) receiving tirzepatide 15 mg weekly achieved a mean weight loss of 20.9% over 72 weeks, compared to 3.1% with placebo
Compared to traditional opinions on insulin, it may be that insulin is not the best choice for all patients with DPN, and some of these newer medications may be better choices [55, 56]
Another study found that patients with OUD and type 2 diabetes had an approximately 40%70% lower risk of overdose if they were prescribed semaglutide compared to another class of diabetes medication (Wang W et al, JAMA Netw Open 2024;7(9):e2435247)
While research continues, existing patches have not demonstrated therapeutic efficacy comparable to injections in clinical trials
Said to enhance fat loss by prioritizing adipose cell fat burning for energy, helping break weight loss plateaus