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GLP-1 receptor (GLP-1R) is widely distributed in the central nervous system, mainly in neurons (Vrang and Larsen, 2010), with high expression in glutamatergic neurons of the area postrema (AP) and nucleus of the solitary tract (NTS) (Yaribeygi et al., 2021)
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Glucagon-like peptide 1 (GLP-1) has this capability but exactly how it exerts its glucagonostatic effect remains obscure
Induced pluripotent stem cell (iPSC)-derived human liver organoids (iHLOs) are particularly promising, as they can recapitulate the cellular complexity of the liver, including diverse cell types such as hepatocytes, cholangiocytes, endothelial cells, and occasionally Kupffer cells 11