Modern-day keto tends to focus on weight loss, through limiting carbohydrates
Beyond this direct chemical defense, NO also functions as a critical signaling molecule, modulating protein function through regulatory S-nitrosylation to actively suppress the ferroptotic cascade
Indeed, the levels of several tight junction proteins, measured by Western blots, including occludin and ZO-1 were decreased in hypertensive models in some studies [92, 94], but not others, where differences in colonic occludin or ZO-1 between hypertensive and normotensive animals was not detected when these were assessed by immunofluorescence [93]
[PubMed: 29980055] 705
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