glutathione bioavailability Study of an Innovative Orobuccal Formulation of - Buonocore - 2016 - Oxidative Medicine and Cellular Longevity liposomal glutathione bioavailability randomized controlled

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Feldman et al., 2022)

doi: 10.1038/s41467-020-17648-w 72 PollackCVJr.KurzMAHaywardNJ

19(1):C7-C11

Scientific Relevance Epithalon is extensively studied in laboratory models for gerontology and bioregulation

At the cellular level, vitamin B12 is involved in DNA synthesis and neuroprotection, acting as a cofactor for enzymes critical to these processes, such as methionine synthase and methylmalonyl-CoA mutase (, )