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Lawsuits against Novo Nordisk claim that it failed to warn users of the risk of the following side effects: Vision loss or changes Gastroparesis (stomach paralysis) Neuropathy with gastroparesis Intestinal blockage (often requiring surgery to repair) Cyclical vomiting Pancreatic cancer Necrotizing pancreatitis Gallbladder disease Blood clots Has Trulicity Harmed You

With regards to specific outcomes such as HF, there has been heterogeneity in the results with both GLP-1RAs and DPP-4i

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Compared with untreated controls, microsomal protein concentrations were increased after twenty-eight days of treatment in C57BL mice, after four and twenty-eight days of treatment in C3H mice, after four days of treatment in B6C3F1 mice, and with no effect of treatment in C3B6F1 mice