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2006;11(1) Adami LNG, Belardin LB, Lima BT, et al

The synergistic effect on cGMP is believed to be responsible for the effects on blood pressure

Polyak, C.Gamberi, Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease

Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121