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doi: 10.1523/JNEUROSCI.21-15-05652.2001

These changes can affect skin elasticity, recovery from injury, and overall cellular resilience

This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)