When assessing for folate deficiency, consider checking red blood cell folate level (instead of serum folate level)
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[12] Following deep intramuscular or subcutaneous administration, estradiol cypionate forms a depot from which the lipophilic ester diffuses slowly into the systemic circulation
Systemic side effects may include nausea, gastrointestinal upset, flushing, and, in rare cases, allergic reactions such as rash, hives, or anaphylaxis