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For presynaptic excitatory transmission the VGLUTi (Synaptic Systems, Goettingen, Germany) marker (Balschun, Moechars et al.) was employed and for general presynaptic transmission synapsinl (Synaptic Systems, Goettingen, Germany) (Ferreira and Rapoport 2002) was applied

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Just take it from the research: In clinical trials of Zepbound, for example, people taking the highest dose of the drug (15 mg) lost an average of 20.9% of their body weight over the course of 72 weeks

Until the labs answer it, "more powerful" is a pharmacological description not a treatment rationale

PMID 24485345