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There is also the counteraction of cognitive dysfunction exemplified through the novel object recognition test as a particular negative-like symptom [204,205,206,207] in the schizophrenia model (acute ketamine treatment (3 mg/kg i.p.)) [171]

This gastric stability fed the hypothesis of oral bioavailability, a hypothesis nevertheless difficult to rigorously validate because animal studies predominantly use intraperitoneal or subcutaneous routes

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