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IGF-1 , whose production is stimulated by GH, inhibits GH release in a biphasic manner: (1) by stimulating hypothalamic somatostatin release early, and (2) by inhibiting GH release after 24 hours, probably by inhibiting GH mRNA transcription (451,452)

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FIGURE 3 Furthermore, nitric oxide (NO) serves multiple physiological functions, acting as a neurotransmitter in the nervous system, preserving vascular homeostasis, and regulating immune responses (Tuteja et al., 2004

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