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In addition to genetics, other hyperuricaemia/gout risk factors include: 1, 5, 6 Older age Male sex Obesity Cardio-metabolic co-morbidities, particularly CKD, hypertension and hyperlipidaemia Use of medicines that influence urate production, reabsorption or excretion, e.g

In the case of bacterial overgrowth and metabolic imbalances, endotoxemia can occur where bacterial toxins, including lipopolysaccharides (LPS) enter the body, contributing to symptoms and disease

This is the process known to be responsible for significant damage to - and premature ageing of - our cells

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doi: 10.1039/D2BM01762A 174 AggarwalSSullivanR