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(Figure.) About 90 percent of the drug is conjugated to sulfate or glucuronide after a therapeutic dose, forming nontoxic metabolites that are excreted harmlessly in the urine

Skin feels calmer and less irritated 3

10.1016/j.cmet.2022.09.021 191 YangJ.KimJ

301 In addition, SGLT-2i still showed a remarkable cardiovascular benefit in nondiabetic patients, indicating that SGLT-2i had a blood glucose-independent effect on improving cardiovascular outcomes