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Using standard sterile water without the bacteriostatic agent significantly reduces this safety window, potentially compromising both medication integrity and patient safety

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Endothelin-1 receptor A blocker darusentan decreases hepatic changes and improves liver repopulation after cell transplantation in rats

Consequently, the translational relevance of current clinical data should be interpreted with caution, and larger, well-controlled trials with standardized dosing strategies are needed

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