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It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production (Ikeda et al., 2018)

Fruits are good but limit to no more than two daily servings, especially if insulin resistant

After 12 months, participants achieved an average weight loss of 15.6%, and 73% of those with diabetes or prediabetes reached A1C levels under 5.7%

With GLP-1 identified, researchers immediately recognized its therapeutic potential: if one could harness GLP-1s potent glucose-lowering and appetite-suppressing effects , it might become a treatment for diabetes or even obesity