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The gut bacteria make more GLP-1, which then activates the same receptors that medications target

K., Xu, K., Sun, Y

In a Phase II study, the CD19-targeting CAR-T mivocabtagene autoleucel demonstrated significant improvement in individuals with stiff person syndrome, with a 46% median improvement in a timed 25-foot walk at week 16 and sustained B-cell depletion without high-grade cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome