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This is similar to what researchers observe with semaglutide getting warm and with tirzepatide left out of the fridge

Importantly, while GLP-1 inhibits glucagon release to reduce hepatic glucose output, GIP can stimulate glucagon secretion under certain conditions, such as low glucose states, which may represent an adaptive mechanism to maintain glucose supply during fasting or stress 3

doi: 10.3389/fpls.2017.01720 38 KoramutlaM

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