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Acylcarnitines produced as products of incomplete mitochondrial fatty acid oxidation have been detected in obesity, type 2 diabetes, cardiovascular disease, encephalopathy, and diseases of the eye, while patients with peroxisomal biogenesis disorders, such as Zellweger syndrome or X-linked adrenoleukodystrophy, or with acidemias have abnormal profiles of circulating acylcarnitines

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doi: 10.1007/s00421-011-2154-2 150 Tyszkiewicz-NwaforMJowikKDutkiewiczAKrasinskaAPytlinskaNDmitrzak-WeglarzMet al

These measurements were further interpreted in the context of ROS accumulation and antioxidative enzyme activities to delineate oxidative stress responses

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