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This is particularly relevant for: Short-acting agents (exenatide immediate-release, lixisenatide) May require timing separation from oral medications, particularly those requiring rapid absorption Weekly agents (semaglutide, dulaglutide, exenatide extended-release) Generally have minimal impact on oral contraceptive effectiveness Warfarin/coumarin anticoagulants More frequent INR monitoring may be advised when starting GLP-1 therapy Oral semaglutide (Rybelsus) has specific administration requirements (taking on an empty stomach with a small amount of water) to ensure proper absorption

If you're having surgery, it's essential to let your anaesthetist know you're on a GLP-1 medication, as they slow down digestion and may increase your risk of complications under anaesthetic