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A 2025 orthopaedic sports medicine systematic review describes increasing use despite lack of FDA approval and bans in sport, and emphasizes that the evidence base is dominated by preclinical studies with limited high-quality human data

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Following a sermorelin dose, the increase in circulating GH leads to a corresponding rise in IGF-1 production primarily from the liver, which mediates many of the growth-promoting and metabolic effects of GH

However, as with any supplement that impacts internal chemistry, questions about safetyspecifically regarding the kidneysare common

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