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It was more likely to be associated with gallstones, also called cholelithiasis, with an incidence of 2.5%, compared to 1.6% for injectable semaglutide and 1.0% for placebo

Hum Mutat 34 (9): 1250-9, 2013

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Potential Cardiovascular Benefits: Some preliminary research suggests that Tirzepatide may have positive effects on cardiovascular health