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However, the modelling of chemical toxicology and in particular metabolic processes in vitro is fraught with many challenges, including the use of a proliferating rather than a quiescent cell, limited retention of metabolic activities in immortalised cell lines, and the poor recapitulation of the in vivo metabolic environment and substrate availability

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(2021) Homocysteine, folic acid, cyanocobalamin, and frailty in older people: Findings from the Invece.Ab study, Frontiers in physiology, [online] Available at: (accessed 7 th April 2022) Hamlin, J.C., Pauly, M., Melnyk, S., Pavliv, O., Starrett, W., Crook, T.A