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Acetylation of p53 protein at lysine 120 up-regulates Apaf-1 protein and sensitizes the mitochondrial apoptotic pathway

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Incretin was forgotten for three decades until the discovery by McIntyre [4] that stated that intestines released some humoral substances, after glucose ingestion, that helped to promote -cellular secretion of insulin, followed by the introduction by Unger and Eisentrout of the concept of entero-insular axis [5]

For example, exposure of mouse AD model to either enriched environment or voluntary physical activity, or combination of both reversed astrocytic atrophy and decreased -amyloid load