Breakthrough medications like Semaglutide (marketed as Ozempic and Wegovy) have demonstrated not only significant metabolic benefits but also cardiovascular improvements, establishing them as blockbuster therapies
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Importantly, tricyclic antidepressants, especially amitriptyline and nortriptyline, worsen the metabolic profile, increasing insulin resistance, contributing to weight gain and causing hyperglycemia, thereby increasing the risk of diabetes with prolonged use [77]
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