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ALS can also be genetically categorized as being either sporadic ALS (SALS) that represents 9095% of all diagnoses and in which there is no known direct genetic contribution to the disease, or familial ALS (FALS) that makes up the remaining 510% of all cases where known genetic mutations such as in SOD1, TDP-43, FUS, and C9ORF72 predominate (Zarei et al., 2015)

Metz CH, Schroder AK, Overbeck S, Kahmann L, Plumakers B, Rink L

Publications Journal Impact Factor Most Recent Cell Metab2025 Dec 29:S1550-4131(25)00530-3

The conversion of pyridoxamine to pyridoxal 5-phosphate c

Targeting mitochondrial structure sensitizes acute myeloid leukemia to venetoclax treatment