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Furthermore, monocyte-derived macrophages are among the first, and most abundant, immune cells to traffic into the islet in both murine models and human patients (63), and it is hypothesized that this initial influx is induced by increased levels of CCL2

[ [PMID: 16807415] Thyroid , 2015 , 25 (1), 118-124

Why the 7-Day Window Matters Steady State Accumulation: Injecting every seven days allows the medication to build up to a therapeutic level over several weeks without reaching toxic or overwhelming concentrations