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The number of cells and the extracellular matrix of glomeruli is reduced to alleviate kidney fibrosis by HKC and reverse the increase in the markers of oxidative stress, such as malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine, total superoxide dismutase (SOD), and nicotinamide adenine dinucleotide phosphate oxidase-4 [39]

There is, however, a synthetic analog of TH4 called TB-500, which has been investigated as a treatment for neurodegenerative conditions like multiple sclerosis, but its use is still largely experimental [4]

[DOI] [PubMed] [Google Scholar] 59.Xia L., Wang H., Munk S., Kwan J., Goldberg H.J., Fantus I.G., Whiteside C.I

Moreover, some individuals might've allergies to the preservative, leading to adverse reactions