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Functional and phenotypic analyses confirm the induction of a pancreatic endocrine fate, including positive dithizone (DTZ) staining indicative of insulin production, as well as the upregulation of key pancreatic markers such as Nestin , PDX-1 , paired box gene 4 ( PAX4 ), neurogenin 3 ( NGN3 ), Isl-1, MAFA, insulin, and glucose transporter 2 ( GLUT2 )

Wang Y, Ma J, Tong Y, Li N, Li J, Qi Z (2024) Antidiabetic effects and mechanisms of Cyclocarya paliurus leaf flavonoids via PIK3CA

In vitro models fail to fully recapitulate the complexity of human ocular diseases, leading to inconsistent translational outcomes

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