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48 Furthermore, research from 1997 found that, in healthy men, folic acid supplementation reduced homocysteine levels in all tertiles except the lowest tertile, in which average baseline levels of homocysteine were 7.07 mol/L

This region contains olfactory neurons that extend cilia into the mucus layer and project axons through the cribriform plate to synapse in the olfactory bulb, allowing drugs to bypass the BBB and reach the CNS directly via the olfactory and trigeminal nerve pathways (Crowe et al., 2018)

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The largest group of drugs being monitored by the EMCDDA is synthetic cannabinoids, with 209 different synthetic cannabinoids reported between 2008 and 2021 - including 11 new cannabinoids identified for the first time in 2020