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For instance, cytokines like tumor necrosis factor-alpha (TNF-) can phosphorylate IRS-1 at serine residues, thereby inhibiting its role in the insulin signaling pathway ( Recent studies have demonstrated that GPS significantly enhances insulin sensitivity, as evidenced by both animal models and in vitro cellular experiments ( GPS has the potential to influence the secretion of adipokines, including adiponectin and resistin, which are critical regulators of insulin sensitivity

[12] [13] Readers should note that final peer-reviewed results from this programme are still emerging, and specific percentage figures may change as the full dataset is published

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