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Minocycline acts by inhibiting MMP-9 and the p38 mitogen-activated protein kinase signaling pathways, thereby reducing the production of glutamate, IL-1, and NO by microglia [305]

As a result, these interventions boost the efficacy of chemotherapeutic agents, markedly suppressing breast tumor growth in preclinical animal models of breast cancer [127,128,129,130,131,132, 134]

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