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If those initial dosages don't have an effect, a doctor may recommend increasing the dosage again, going up to one milligram

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PubMed, Edenberg, Howard J

This high metabolic rate leads to increased production of reactive oxygen species (ROS) as byproducts of cellular respiration.Presence of Redox-Active Metals: The brain contains transition metals such as iron and copper, which can catalyze the formation of highly reactive hydroxyl radicals through the Fenton reaction.Limited Regenerative Capacity: Unlike some other tissues, neurons have limited regenerative capacity