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Despite GLP-1 concentration being higher in the fundus than the antrum, its release ex vivo upon IBMX stimulation increases to the same extent in both the fundus and antrum, suggesting a significant contribution to both portal and gastric GLP-1 (Ribeiro-Parenti et al., 2021)

The mechanisms of the two are quite different, although both refer to the color change of the skin

Tirzepatide (Zepbound) Mechanism: Dual GLP-1/GIP agonist targets two hunger hormones

Appetite suppression remains profound but becomes predictable

Your journey will be unique, but heres a general idea of what you can expect and what might influence your progress