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Agonism of GPR119 in both healthy or diabetic and obese mice, is known to improve glucose tolerance (90), or even prevent atherosclerosis in mice (332), while at the same time inducing the secretion of glucagon under low glucose levels avoiding hypoglycaemia (91)

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Definition Research-use-only (RUO): A regulatory and labeling designation for laboratory reagents not intended for diagnostic, therapeutic, or human or veterinary use

5, suggesting that skeletal muscle outcomes during chronic energy restriction may depend more strongly on substrate availability than on drug signaling alone

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