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The mechanistic basis remains undefined

As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine

Sci Rep 13(1):2096

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PMID: 33934676 Nogueira LFR, Crispim CA, Cipolla-Neto J, de Castro Moreno CR, Marqueze EC (2022) The effect of exogenous melatonin on eating habits of female night workers with excessive weight