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Among those who continue treatment, most report that the worst GI side effects occur during the first weeks of initiation or dose escalation and then improve

staying hydrated and using gentle stool softeners (not stimulant laxatives) usually resolves this without requiring medication changes

12 Single doses of more than 150 mg/kg or 7.5 g in adults have been considered potentially toxic, although the minimal dose associated with liver injury can range anywhere from 4 to 10 g

Works on dark spots, tanning, and dullness

Recent headlines about semaglutide shortages have sparked patient concern, but the medication remains accessible through licensed compounding pharmacies across all 50 states