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First, all the rats were anesthetized via an intraperitoneal injection of 2% pentobarbital sodium (75 mg/kg), and the hair of the right posterior leg was removed

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NNMT's job: Take nicotinamide (a NAD+ precursor) and methylate it essentially tagging it for disposal

In critical sized segmental defect in a rat radius, application of inorganic bone matrix together with P-15 resulted in positive effect on bone healing, without any immunogenic features and disease transmission risk [133]