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Sinclair was sitting at his desk at Harvard one day in 2010 when a colleague called to offer his heartfelt sympathies: Pfizer scientists had just released a paper essentially saying that Sinclairs work on sirtuins was bunk

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While these proteins are important antioxidative enzymes in mammals, the plant forms have a different catalytic mechanism and several independent studies strongly suggest that they preferentially use thioredoxins as reductant (Herbette et al