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174 Previous studies have reported the comprehensive effects of GLP-1RA on the CNS, which go beyond the levels of blood glucose modulation, but are associated with numerous metabolic aspects such as food intake and preference, 127,175 water intake, 176 energy expenditure, 177 body weight reduction, 178 pancreatic function, 132,179,180 hypertension, 181 stress, 182 addiction behaviors, 183,184 as well as neurodegenerative disorders, such as Alzheimer and Parkinson diseases

This decline can result in high cholesterol levels, weakened bone strength, and an increased risk of heart disease

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All animal experiments were approved by the Institutional Animal Care and Use Committee of Xinhua Hospital affiliated with Shanghai Jiao Tong University School of Medicine and were conducted in accordance with Guide for the Care and Use of Laboratory Animals (National Research Council 1996, USA)