Pfizer's danuglipron, once considered the primary competitor, was discontinued in April 2025 after a case of potential drug-induced liver injury in a dose-optimization study, following the earlier termination of lotiglipron in 2023 for similar hepatic concerns
Oral versions may help, but adoption lags despite benefits for heart, metabolism, and liver
Through dedicated protein and peptide engineering efforts, we managed to create the first ever oral biologic of its kind - oral semaglutide for type 2 diabetes launched in 2019
[Google Scholar] [2].Faraji N, Ebadpour N, Abavisani M, Gorji A
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