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Additionally, liver injury activates hepatic stellate cells (HSCs), which secrete transforming growth factor- (TGF-) and collagen, ultimately driving liver fibrosis [44]

These findings suggest that certain cytokines might exert positive or negative effects on different tissues, suggesting that tissue-specific targeted therapy is an essential strategy to protect other normal tissues, such as the ovary, from NRTP-induced damage

Protein carbonyl groups as biomarkers of oxidative stress

Homocysteine has been identified as a pathogenic feature of NAFLD in humans and alcoholic fatty liver disease in a rodent model