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RNA sequencing Total RNA was isolated from the pancreatic islets of mice in the NC + saline, HFD + saline, and HFD + Exe groups using TRIzol reagent (T9424, Sigma-Aldrich)

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According to current ADA Standards of Care, therapy selection should be individualized based on comorbidities, weight considerations, hypoglycemia risk, and patient preferences

Through GLP-1 receptor activation, it sends fullness signals to the brain, while GIP receptor activation enhances insulin sensitivity and metabolic control

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