The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions
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3.2 Loss of moisture Freshly harvested shiitake mushrooms can contain up to 90% moisture (on a wet basis), and the decrease in moisture content during preservation plays a pivotal role in determining the overall quality of the fresh mushroom (43)
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