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(Cochrane Skin Group) (December 2018)

Empirical antioxidant use should be supplanted by evidence-based, biomarker-guided therapy to optimize treatment effectiveness and reduce the risk of adverse effects [43]

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Biomarkers including HbA1c, fasting insulin, lipid profiles, and body composition measurements provide the quantitative feedback needed to determine whether the combined approach is producing the intended metabolic effects, whether adjustments to formulation or dosing are needed, and whether the balance between the two therapies remains appropriate as a woman's physiology evolves through and beyond the menopausal transition