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Prdida de peso (en pacientes sin DM2): en STEP-1 (2,4 mg/semana), prdida media de 14,9 % del peso en 68 semanas (placebo 2,4 %) (2,4)

It is directly involved in development of cardiometabolic diseases, ischemic coronary heart disease peripheral arterial disease, heart failure, and arterial hypertension, producing global morbidity and mortality

[11] [12] For weight management, NICE (TA875, TA664) recommends these medications for adults with a BMI of 35 kg/m or more (or 32.5 kg/m or more for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds) who have at least one weight-related comorbidity and are receiving care through specialist weight management services

Because compounded drugs are not FDA-approved, equivalence claims are misleading and actionable

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